Publications

Anthony Weiss examines how the science of the brain can inform our understanding of mental health, leadership, and institutional design. From the role of brain health in the modern economy, to the regulatory principles that shape effective leadership, to the ethical questions raised by increasingly networked cognitive environments, his scholarship investigates how human cognition operates across brains, bodies, relationships, and institutions—and how these systems can be designed to support resilience, responsibility, and well-being.

  • Empirical and translational work on learning, memory, and the biology of intervention.

    Weiss AP, Keshavan M, and Torous J.
    Mental Health AI Chatbots as Pharmakon: A Tripartite Theory of Use Despite Risk. Psychotherapy and Psychosomatics (2026)

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    Weiss AP, Ellis CB, Roffman JL, Stufflebeam S, Hämäläinen MS, Duff M, Goff DC, Schacter DL.
    Aberrant Frontoparietal Function During Recognition Memory in Schizophrenia: A Multimodal Neuroimaging Investigation.
    Journal of Neuroscience 29 (36): 11347–59 (2009).

    Summary: Integrated fMRI and MEG evidence revealing disrupted frontoparietal coordination during memory retrieval—a bridge between systems neuroscience and clinical psychiatry.
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    Dougherty DD, Weiss AP, Cosgrove GR, Alpert NM, Cassem EH, Nierenberg AA, Price BH, Mayberg HS, Fischman AJ, Rauch SL.
    Cerebral Metabolic Correlates as Potential Predictors of Response to Anterior Cingulotomy for Treatment of Major Depression. Journal of Neurosurgery 99 (6): 1010–17 (2003).

    Summary: Identified metabolic signatures of treatment response in patients undergoing anterior cingulotomy—linking neuroimaging, affective circuitry, and therapeutic intervention.

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    Montoya A, Weiss AP, Price BH, Cassem EH, Dougherty DD, Nierenberg AA, Rauch SL, Cosgrove GR.
    Magnetic Resonance Imaging–Guided Stereotactic Limbic Leukotomy for Treatment of Intractable Psychiatric Disease.
    Neurosurgery 50 (5): 1043–49 (2002).

    Summary: A rare modern investigation of ablative neurosurgery in psychiatry, combining clinical, ethical, and neuroanatomical perspectives.

    ______________________________Weiss AP, Dodson CS, Goff DC, Schacter DL, Heckers S.
    Intact Suppression of Increased False Recognition in Schizophrenia.
    American Journal of Psychiatry 159 (9): 1506–13 (2002).

  • Weiss AP.
    Optimizing autonomy in a relational framework: The example of supported decision-making. American Journal of Bioethics Neuroscience (2026)
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    Weiss AP.
    Process variation as friend and foe: Rethinking safety in complex adaptive systems. Joint Commission Journal on Quality and Patient Safety 52 (4): 143 (2026)

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    Weiss AP., Guidi J, Fava M.
    Closing the Efficacy–Effectiveness Gap: Translating Both the What and the How from Randomized Controlled Trials to Clinical Practice. Journal of Clinical Psychiatry 70 (4): 446–49 (2009).

    Summary: Highlights the challenge of translating scientific evidence into practice—linking clinical outcomes to system design.
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    Weiss AP.
    Measuring the Impact of Medical Research: Moving from Outputs to Outcomes. American Journal of Psychiatry 164 (2): 206–14 (2007).

    Summary: A single-authored essay redefining success in medicine as improved societal impact, not publication volume.

    ______________________________Weiss AP et al.
    Patient and Practice-Related Determinants of Emergency Department Length of Stay for Patients with Psychiatric Illness. Annals of Emergency Medicine (2012).

    Summary: Defines the patient-flow and system-level factors shaping emergency-department performance.

  • Exploring how healthcare organizations learn, adapt, and sustain safety, equity, and human dignity.

    Gorrindo T, Goldfarb E, Birnbaum RJ, Chevalier L, Meller B, Alpert J, Herman J, Weiss AP.
    Simulation-Based Ongoing Professional Practice Evaluation in Psychiatry: A Novel Tool for Performance Assessment. Joint Commission Journal on Quality and Patient Safety 39 (7): 319–23 (2013). doi: 10.1016/s1553-7250(13)39045-x. PMID 23888642.

    Summary: Demonstrated how web-based simulation and competency metrics can transform professional practice evaluation at scale within academic medicine.
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    Chang G, Weiss AP et al.
    Bottlenecks in the Emergency Department: The Psychiatric Clinician’s Perspective.General Hospital Psychiatry (2012).

    Summary: Identifies operational inefficiencies that affect safety and quality of care in emergency psychiatry.

  • Weiss AP.
    Beyond the Dementia Dyad: Rethinking Capacity in a Distributed Mind. American Journal of Bioethics 26 (4): 67-69 (2026)

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    Interrogating the moral and organizational frontiers of artificial intelligence, digital health, and clinical practice.

    Weiss AP.
    Adaptive Machine Learning Systems in Medicine: More Learner, Less Machine. American Journal of Bioethics (2024).

    Summary: Argues for reframing AI in healthcare as a dynamic learning partner rather than a static tool—linking machine adaptation to biological allostasis.

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    Morrell W, Shachar C, Weiss AP.
    The Oversight of Autonomous Artificial Intelligence: Lessons from Nurse Practitioners as Physician Extenders. Journal of Law and the Biosciences 9 (2): lsac021 (2022). PMID 35968225.

    Summary: Examines how delegated clinical authority can inform responsible models for AI oversight.

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    Weiss AP & Richman BD. Professional Self-Regulation in Medicine: Will the Rise of Intelligent Tools Mean the End of Peer Review? In I. Glenn Cohen (ed.), The Future of Medical Device Regulation. Cambridge University Press (2021).

    Summary: Explores how algorithmic systems challenge medicine’s traditions of judgment and accountability.
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    Weiss AP, Sato L, Richman BD. How AI Will Change the Regulation and Organization of Medicine. Health Affairs Blog (2020).

    Summary: Discusses how adaptive AI systems could reshape professional hierarchies and institutional learning.
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    Martinez-Martin N, Dasgupta I, Weiss AP et al.
    Ethics of Digital Mental Health During COVID-19: Crisis and Opportunities. JMIR Mental Health (2020).

    Summary: Analyzes data ethics, surveillance, and privacy concerns arising from rapid digitalization in mental-health care.

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    Emerging Issues Task Force of the International Neuroethics Society (incl. Weiss AP).
    Neuroethics at 15: The Current and Future Environment for Neuroethics. American Journal of Bioethics: Neuroscience (2019).

    Summary: Defines priorities for the field of neuroethics at a moment of accelerating technological change.

“Medicine advances not only through discovery, but through reflection - on how knowledge is created, applied, and translated into care.”

- Anthony Peter Weiss

“The human brain is an extraordinarily energy-intensive organ. In modern societies, where knowledge work and decision-making dominate economic activity, the brain has become our most valuable productive asset.”

Read Dr. Weiss' Work
Speaking & Collaboration